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RENAL CALCULUS

Renal stone or calculus or lithiasis is one of the most common diseases of the urinary tract. It occurs more frequently in men than in women and in whites than in blacks. It is rare in children. It shows a familial predisposition.

Urinary calculus is a stone-like body composed of urinary salts bound together by a colloid matrix of organic materials. It consists of a nucleus around which concentric layers of urinary salts are deposited.

Aetiology

(1) Hyperexcretion of relatively insoluble urinary constituents such as oxalates, calcium, uric acid, cystine and certain drugs (such as magnesium trisilicate in the treatment of peptic ulcer).

(2) Physiological changes in urine such as Urinary pH (which is influenced by diet and medicines), Colloid content, Decreased concentration of crystalloids, Urinary magnesium/calcium ratio.

(3) ALTERED URINARY CRYSTALLOIDS AND COLLOIDS

· Either there is an increase in the crystalloid level or a fall in the colloid level, urinary stones may be formed.

· If there is any modification of the colloids e. g. they lose their solvent action or adhesive property, urinary stones may develop.

(4) DECREASED URINARY OUTPUT OF CITRATE

(5) VITAMIN A DEFICIENCY

· The desquamated cells form nidus for stone formation. This is more applicable to bladder stones.

(6) URINARY INFECTION

· Infection disturbs the colloid content of the urine, also causes abnormality in the colloids (which may cause the crystalloid to be precipitated).

· Infection also changes urinary pH and also causes increase in concentration of crystalloids.

(7) URINARY STASIS

· It causes a shift of the pH of the urine to the alkaline side, predisposes urinary infection, and allows the crystalloids to precipitate.

(8) HYPERPARATHYROIDISM

· Due to overproduction of parathormone the bones become decalcified and calcium concentration in the urine is increased. This extra calcium may be deposited in the renal tubules or in the pelvis to form renal calculus.

(9) Prolonged immobilisation

(10) NIDUS OF STONE FORMATION

ENVIRONMENTAL AND DIETARY FACTORS

(a) Low urine volumes

(b) High ambient temperatures

(c) Low fluid intake

(d) Diet

(e) High protein intake

(f) High sodium

(g) Low calcium

(h) High sodium excretion

(i) High oxalate excretion

(j) High urate excretion

(B) OTHER MEDICAL CONDITIONS

(a) Hypercalcemia of any cause

(b) Ileal disease or resection (leading to increased oxalate absorption and urinary excretion)

(c) Renal tubular acidosis type I

(C) CONGENITAL AND INHERITED CONDITIONS

(a) Familial hypercalciuria

(b) Medullary sponge kidney

(c) Cystinuria

(d) Renal tubular acidosis type I

Types of renal calculi

Basically the renal stones can be divided into two major groups

I. Primary stones

II. Secondary stones.

(I) PRIMARY STONES

They appear in apparently healthy urinary tract without any antecedent inflammation.

(a) Calcium oxalate

(b) Uric acid calculi

(c) Cystine calculi

(d) Xanthine calculi

(e) Indigo calculi

(II) SECONDARY STONES

They are usually formed as the result of inflammation.

(a) Triple phosphate calculus

(b) Mixed stones

SYMPTOMS

(a) Quiescent calculus

(b) Pain

· Fixed renal pain

· Ureteric colic

· Referred pain

(c) Hydronephrosis (a lump in the loin and a dull ache)

(d) Haematuria

(e) Pyuria